May 2, 2022 · At the molecular level, human MRN and yeast Mre11-Rad50-Xrs2 (MRX) promote DNA double-strand break (DSB) repair via non-homologous end joining (NHEJ) and homologous recombination (HR) by...

Jan 9, 2014 · MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) remains enigmatic.

Jul 26, 2009 · Eukaryotic cells have two well-characterized DNA double-strand break (DSB) repair pathways. Homologous recombination accurately repairs postreplicative DSBs using an intact template from a...

In addition, the MRE11 complex regulates DSB repair, through the homology directed repair (HDR), non-homologous end-joining (NHEJ; also known as classical (C)-NHEJ) and alternative non-homologous end-joining (A-NHEJ) pathways (fig. 1; for reviews, see refs 5, 6).

Lactate-induced MRE11 lactylation in cancer cells leads to HR hyperactivation and chemoresistance. The findings unveil new insights into the ways in which cellular metabolism is tied to DSB repair and the impact of the Warburg effect on chemoresistance.

MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) remains enigmatic.

Jan 8, 2010 · We demonstrate that the MRE11-RAD50-NBS1 (MRN) complex acts to promote DNA end resection and the generation of single-stranded DNA, which is critically important for HR repair.

Aug 16, 2016 · We show that although Mre11 is required for efficient HR-dependent repair of ionizing-radiation–induced DSBs, Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.

Jul 1, 2020 · The text immediately below focuses on the removal of protein blocks by the MRE11 nuclease, in the context of DSB repair by the recombination pathway. The ability of the MRE11 complex to cleave 5′-terminated DNA past protein blocks is conserved in evolution.

Sep 7, 2017 · DNA double-strand break (DSB) repair is essential for maintaining our genomes. Mre11-Rad50-Nbs1 (MRN) and Ku70-Ku80 (Ku) direct distinct DSB repair pathways, but the interplay between these complexes at a DSB remains unclear.