The Munc13 gene family encodes molecules located at the synaptic active zone that regulate the reliability of synapses to encode information over a wide range of frequencies in response to …

Endogenous Munc13-1 showed a clear punctate localization, which overlapped with synapsin-mCherry. In contrast, overexpressed Munc13-1 was not restricted to synapses but distributed …

Munc13 contributes to a remaining functional RRP after active zone disruption. Given the further reduction of synaptic transmission when Munc13 is ablated in cKO R+E neurons, we analyzed …

Munc13 is a multidomain protein of presynaptic active zones that mediates the priming and plasticity of synaptic vesicle exocytosis, but the mechanisms involved remain unclear.

Aug 8, 2020 · In this study, we have identified a number of residues in domain 3a of Munc18‐1 that are crucial for Munc13 and Munc18‐1 actions in SNARE complex assembly and synaptic …

UNC-13-Munc13s have a central function in synaptic-vesicle priming through their MUN domains. However, it is unclear whether this function arises from the ability of the MUN domain to …

Dec 15, 2021 · Using knockin mouse lines with point mutations in the Ca 2+ -phospholipid-binding C 2 B domain of Munc13-1, we demonstrate that abolishing Ca 2+ -phospholipid binding …

We found that RIM modulates synaptic vesicle localization in the proximity of the active zone membrane independent of Munc13-1. In another step, both RIM and Munc13 mediate synaptic …

Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary SNARE complex. Here we report a new function of Munc13, independent of Munc18: it …

May 8, 2013 · We addressed this issue at the calyx of Held synapse, a giant glutamatergic synapse that we found to express all these Munc13 isoforms. We studied their roles in the …