The sodium-calcium exchanger (often denoted Na + /Ca 2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells.

The plasma membrane Na + /Ca 2+ exchanger is a high‐capacity and low affinity ionic transporter that exchanges three Na + ions for one Ca 2+ ion.

Oct 4, 2023 · Sodium-calcium exchangers (NCX) are membrane antiporters that control the extrusion or entry of Ca 2+ across the cell membrane in exchange for Na + 1, 2, 3, 4. They are ubiquitously expressed...

Plasma membrane Na + –Ca 2+ exchangers are vital for controlling cytosolic calcium concentrations in many tissues, particularly in excitable cells. There are two distinct families of Na + –Ca 2+ exchangers, the NCX (SLC8) family and the NCKX (SLC24) family.

Free energy stored in a non-equilibrium gradient of concentrations across a membrane can be used by an antiporter ("exchanger") to pump another molecule against its gradient. Membrane-embedded transporter proteins can function as machines because binding events are coupled to conformational changes.

The Na + /Ca 2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells.

We examine this self-regulated mechanism using a homolog of the cardiac Na+/Ca2+ exchanger as a model system. Using advanced computer simulations, we map out the complete functional cycle of...

Nov 1, 1994 · The cardiac Na + /Ca 2+ antiporter moves 3 Na + across the plasma membrane in exchange for a single Ca 2+ moving in the opposite direction. It is the principal Ca 2+ efflux mechanism in myocardial cells; however, it also contributes to …

In this article, we develop a mechanistic model of mitochondrial Na + -Ca 2+ antiporter which improves upon and generalizes our previous model (16) and provides a biophysical basis for the ΔΨ-dependency of the antiporter function for a 3Na +:1Ca 2+ exchange.

Jan 20, 2010 · To gain a quantitative understanding of mitochondrial Ca(2+) homeostasis, a biophysical model of Na(+)-Ca(2+) antiporter is introduced that is thermodynamically balanced and satisfactorily describes a number of independent data …