The NCBI sequence databases and software tools are designed around a particular model of biological sequence data. It is designed to provide a few unifying concepts which cross a wide range of domains, providing a path between the domains.

NCBI uses the Genome Reference Consortium (GRC) data model, reflecting the complexity of the modern genome assembly (see Figure 1 below). The data model accounts for all sequences known to represent an organism’s genome, including those that are not yet assigned to chromosome assemblies.

Step-by-step instructions on installing NCBI Datasets command-line tools to retrieve gene, genome, and coronavirus data. Use NCBI Datasets to gather metadata, download data packages, view reports, and more. Request a new feature or submit a bug report by opening an issue in …

This chapter describes the NCBI Biological Sequence Data Model, with emphasis on the ASN.1 files and C++ API. ASN.1 type names and the corresponding C++ class or data member names are used almost interchangeably throughout the chapter.

The SPDI data model defines variants as a sequence of four attributes: sequence, position, deletion and insertion, and can be applied to nucleotide and protein variants. NCBI web services convert representations among HGVS, VCF and SPDI and provide two functions to …

Methods Biochem Anal. 1998:39:121-44. doi: 10.1002/9780470110607.ch6. 1 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.

The National Center for Biotechnology Information (NCBI) has designed a data model to define a number of key data elements for molecular biology, including bibliographic data, nucleic acid sequence, protein sequence, genetic and physical maps, and the information about them.

Apr 20, 2001 · This chapter is a discussion of the actual underlying structure of databases commonly used in sequence analysis. The chapter focuses on the NCBI data model.

We tested the data model on three very different types of commonly available data used by clinical researchers: administrative claims data, EHR data, and cancer registry data.

Oct 18, 2023 · NCBI Datasets is a continually evolving platform designed to provide easy and intuitive access to NCBI’s sequence data and metadata. Why are we making this change? NCBI Datasets is part of the NIH Comparative Genomics Resource (CGR).