Via these interactions, synapsins control several mechanisms important for neuronal homeostasis. In this review, we describe the main functional features of the synapsins, in relation to the complex role played by these phosphoproteins in neuronal development.

Current studies suggest the following hypothesis for the role of synapsin: synapsins bind synaptic vesicles to components of the cytoskeleton which prevents them from migrating to the presynaptic membrane and releasing neurotransmitter.

The synapsins are a family of neuron-specific phosphoproteins that selectively bind to small synaptic vesicles in the presynaptic nerve terminal. The human synapsin I gene was functionally analyzed to identify control elements directing the neuron-specific expression of synapsin I.

Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated evolutionary conservation, have been described to encode for Synapsin I, Synapsin II …

Dec 27, 2017 · Synapsin genes have been associated with several neurological disorders such as schizophrenia, bipolar disorder (BD), AD, MS, Huntington’s disease (HD), and epilepsy, as demonstrated by both genetic and functional studies.

Synapsins I and II are stably expressed at synapses of mature neurons, where they associate with the cytoplasmic surface of small SVs, whereas the expression of synapsin III is developmentally controlled and not strictly confined to synaptic terminals (Fig. 2).

Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated evolutionary conservation, have been described to encode for Synapsin I, Synapsin II …

Synapsin is expressed in nervous tissue of vertebrates and invertebrates (Kao et al., 1999; Candiani et al., 2010) and is a neuron-specific, synaptic vesicle-associated protein implicated in neural development (Fornasiero et al., 2010) and synaptic transmission (Cesca et al., 2010).

Mar 14, 2025 · The Synapsin (Syn) promoter drives neuron-specific gene expression through core promoter elements, upstream regulatory sequences, and enhancer regions. The core promoter contains a TATA box or similar initiator sequences that recruit RNA polymerase II, ensuring accurate transcription initiation.

Mar 19, 2025 · The human synapsin 1 (hsyn) promoter is widely used for neuron-specific expression, making it valuable for neurological research and gene therapy. Understanding its mechanisms helps refine gene delivery strategies and improve studies of the nervous system. Molecular Framework And Synapsin Elements