Sep 10, 2021 · In naive control mice, the proportion of FSC high NK cells is very small. CD71 is a target of cMyc, which is an important general regulator of cellular metabolism and proliferation.

Representative flow cytometry plots from NK cell subsets showing CD71 and CD57 staining in (A) CD56bright and (B) CD56dim subsets at 1 and 6 months of age an HIV-infected infant (B1-093).

More recently, studies have shown IL-21 expanded human NK cells have significantly elevated basal and maximal glycolysis but downregulated OXPHOS compared to peripheral blood NK cells. They also have increased levels of the glucose and amino acid …

Aug 9, 2023 · The MFI of (C) FSC in NK cells indicating cell size, (D) glucose uptake by NK cells as measured by 2-NBDG, and (E) CD71 and CD98 expression of antibody-treated NK cells are presented.

NK cell activation is dependent on integration of signals through cytokine and germline-encoded activating and inhibitory receptors. The availability of metabolic fuels and pathways is required for NK effector functions including proliferation, killing, and production of interferon gamma (IFN-γ).

Indeed, NK cell differentiation is associated to the onset of cell quiescence as shown by the decrease in cell size and glucose uptake concomitant with a loss of the transmembrane nutrient receptors CD71 and CD98.

Jul 20, 2018 · As nutrient availability in blood and tissues can significantly differ, we examined NK cells isolated from paired blood-liver and blood-spleen samples and compared expression of the nutrient transporters Glut1, CD98 and CD71.

Sep 11, 2023 · CD71 has an important role in iron uptake, and many cellular functions — such as DNA synthesis or repair, oxygen transfer and mitochondrial function — are dependent on sufficient...

Jul 20, 2018 · As nutrient availability in blood and tissues can significantly differ, we examined NK cells isolated from paired blood-liver and blood-spleen samples and compared expression of the nutrient transporters Glut1, CD98 and CD71.

May 2, 2021 · The most widely investigated nutrient transporters on immune cells are CD71, the transferrin receptor and CD98 (SLC3A2), a chaperone that forms a heterodimeric system L-amino acid transporter by pairing mainly with SLC7A5 (LAT-1) in NK cells (3, 6, 7, 10 – 12).

Nov 16, 2012 · CD71 (transferring receptor 1) is an integral membrane glycoprotein that plays an important role in cellular uptake of iron. It is well known as a marker for cell proliferation and activation. Although all proliferating cells in hematopoietic system express CD71, however, CD71 has been considered as a useful erythroid-associated antigen.

Jun 1, 2021 · In this study, we investigated the mechanisms for human NK cell dysfunction in the TME. Using models of human ovarian cancer, we found that the TME directly paralyzes NK cell glucose metabolism via lipid-peroxidation-associated …

Jun 14, 2018 · Consistent with normal cMyc expression, NK cells stimulated in the presence of Akti-1/2 were equivalent in size and CD71 expression, and produced comparable levels of IFNγ and granzyme B...

CD71 expression has been found to be significantly increased in rapidly proliferating cells. Methods: This cross-sectional study included 37 bone marrow samples of acute leukemia cases diagnosed between October 2016 to April 2018. The samples were analysed on BD FACS Canto II.

We found a population of highly activated CD56 dim CD16 + NK cells that have recently degranulated, evidence of killing activity, and it is absent in healthy donors.

Jun 25, 2021 · Our recent work has shown that higher expression of the amino acid transporter CD98 and CD71 transferrin receptor does correlate with enhanced NK cell anti-tumor function (Poznanski et al., 2021a). This suggests that NK cells transduced with the control vector may have heightened nutrient uptake capacity leading to some level of non-specific ...

Mar 11, 2016 · Cluster of Differentiation 71 protein (CD71), also known as the Transferrin receptor protein 1 (TfR1) is a protein encoded by the TFRC gene located on chromosome 3q29. It is found as a cell surface membrane protein in humans and is essential for iron delivery to the cells.

CD71 is a highly effective marker for the detection of cells of erythroid lineage in bone marrow biopsy specimens. Accurate analysis of the erythroid lineage is essential in evaluating bone marrow biopsy specimens and can be particularly challenging in the setting of dyserythropoiesis.

Mar 19, 2021 · In accordance, we have found that NK cells increase the expression of the transferrin receptor CD71, the heavy subunit of multiple heterodimeric amino acid transporters CD98, and the glucose...

Jul 20, 2018 · As nutrient availability in blood and tissues can significantly differ, we examined NK cells isolated from paired blood-liver and blood-spleen samples and compared expression of the nutrient...