15 O-water is used as a radioactive tracer for measuring and quantifying blood flow using positron emission tomography (PET) in the heart, brain and tumors.

Currently, positron emission tomography (PET) with [15 O]-water is considered the reference standard for CBF measurements. 2, 3 In a typical experiment, [15 O]-water is injected into the patient and modeled as a freely diffusible tracer that enters into cerebral tissue but is not metabolized. 4 Equilibrium is achieved within a few minutes, such ...

Sep 1, 2024 · Water can be imaged quantitatively using positron emission tomography (PET) together with tracer amounts of oxygen-15 labelled water ( [15 O]H 2 O). [15 O]H 2 O has characteristics that make it an ideal tracer for absolute quantification of blood flow (perfusion).

We will discuss the application of two approaches (oxygen-15 positron emission tomography and functional magnetic resonance imaging) that have recently been used to examine components of learning and memory following traumatic brain injury (TBI).

We have developed, implemented, and validated a method for the measurement of the local cerebral metabolic rate for oxygen (CMRO2) with positron emission tomography (PET).

Nov 30, 2021 · In this chapter, we introduce several 15 O PET methods and provide examples of their applications in studying normal brain physiology and functions, cerebrovascular diseases, and aging.

May 1, 2020 · Background: O-15 labeled compounds, such as water, carbon dioxide and oxygen, are useful PET tracers for visualizing brain perfusion and metabolism. Although O-15 enables radiolabeling of physiological molecules without modifying their chemical characteristics, the shortcomings of O-15 include short half-life (2 minutes) and long positron range ...

We have developed, implemented, and validated a method for the measurement of the local cerebral metabolic rate for oxygen (CMRO2) with positron emission tomography (PET).

May 1, 2020 · Introduction: Oxygen-15 (t ½ = 124s) has been used for nuclear imaging experiments since the beginning of the field. With the advent of simultaneous hybrid PET/MR technology, [15 O]Water has seen a resurgence, particularly for validating novel MR sequences. Indeed, for quantitative blood flow studies it remains the gold standard method.

Jul 1, 2015 · Cerebral hypoperfusion has been suggested as a biomarker for preclinical Alzheimer's disease (AD) and can be used to complement other imaging biomarkers, such as Pittsburgh compound B (PiB)-PET. Arterial spin labelling (ASL) MR is quickly becoming a viable alternative to O15-water PET for measuring cerebral blood flow (CBF) non-invasively and ...