Oxoglutarate dehydrogenase is a key control point in the citric acid cycle. It is inhibited by its products, succinyl CoA and NADH. A high energy charge in the cell will also be inhibitive. ADP and calcium ions are allosteric activators of the enzyme.

Pyruvate dehydrogenase complex (PDHC), OGDHC and branched-chain alpha keto acid dehydrogenase (BCKDC) each catalyze the oxidative decarboxylation of specific alpha keto acids that are recognized by the E1 and E2 subunits.

Feb 2, 2017 · The E1 subunit, encoded by the human OGDH gene, is a dehydrogenase that catalyzes the decarboxylation of α-KG, the first step required to produce succ-CoA.

Dec 25, 2024 · OGDH (Oxoglutarate Dehydrogenase) is a Protein Coding gene. Diseases associated with OGDH include Oxoglutarate Dehydrogenase Deficiency and Movement Disease. Among its related pathways are Citric acid cycle (TCA cycle) and Glyoxylate metabolism and glycine degradation.

Apr 30, 2022 · OGDH complexes (OGDHc) are canonical members that catalyze the oxidative decarboxylation of 2-oxoacids, pyruvate, 2-oxoisovalerate, and 2-oxoglutarate into their corresponding acyl-CoA thioesters, producing the reducing equivalent NADH.

OGDH consists of three protein subunits that catalyze the oxidative decarboxylation of 2-ketoglutarate to succinyl-CoA. α-Ketoglutarate dehydrogenase (OGDH) deficiency was previously reported in association with failure to thrive, hypotonia, weakness, developmental delay, seizures, extrapyramidal symptoms, ataxia, and increased tone with no ...

Here, we show that loss of DHTKD1 in glutaryl-CoA dehydrogenase-deficient HEK-293 cells leads to a 2-fold decrease in the established GA1 clinical biomarker glutarylcarnitine and demonstrate that oxoglutarate dehydrogenase (OGDH) is responsible …

2-Oxoglutarate dehydrogenase (OGDH) of the tricarboxylic acid (TCA) cycle is often implied to be inactive in cancer, but this was not experimentally tested. We addressed the question through specific inhibition of OGDH by succinyl phosphonate (SP).

Jul 7, 2023 · We show that the scaffolding protein Zasp52 recruits the oxoglutarate dehydrogenase complex to coordinate myofibril growth and maintain their regularity. Striated muscles are long contractile cables that bridge two rigid structures, such as bones or regions of the exoskeleton.

Sep 12, 2019 · Consistently, overexpression of OGDH enhanced the mitochondrial function in GC cells. Furthermore, OGDH knockdown reduced the expressions of β-catenin, slug and TCF8/ZEB1, and the downstream targets cyclin D1 and MMP9 in GC cells. OGDH overexpression facilitated the activation of Wnt/β-catenin signal pathway.