Oct 18, 2021 · Plasmacytoid dendritic cells (pDCs) are a special subtype of dendritic cells with the morphology of plasma cells. pDCs produce massive amounts of type I interferon (IFN-I), which …

Sep 15, 2018 · In this review, we discuss the development and function of pDCs as well as their role in innate and adaptive immunity. Finally, we summarize pDC contribution to cancer …

Dendritic cells (DC) represent a major antigen-presenting cell in the tumor immune microenvironment (TIME) and play an essential role in cancer immunity. Clinical relevance of …

Jul 17, 2024 · In the last decade, studies have proposed a relevant role for pDC also in cancer immunity. Their expansion and activation in the tumor tissue by recently developed …

Nov 12, 2020 · Dendritic cells (DC) represent a major antigen-presenting cell type in the tumor immune microenvironment (TIME) and play an essential role in cancer immunity. Conventional …

Similarly to other tumor-infiltrating immune cells, the phenotype and functional capacity of pDC is dependent on the shape of the tumor microenvironment including the pattern of the immune …

Sep 15, 2018 · pDCs have been shown to play regulatory role in several cancers and help tumor progression. Understanding the tumor influence on pDC function in TME can lead to the …

Background: Plasmacytoid dendritic cells (pDCs) play a key role in the induction and maintenance of antitumor immunity. Conversely, they can act as tolerogenic DCs by inhibiting tumor …

Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon.

Aug 1, 2012 · Various studies indicate that pDCs play an immuno-suppressive role and facilitate tumor progression in both animal models and humans. In contrast, others found that the …