Progressive supranuclear palsy is characterized by decreased cognition, abnormal eye movements (supranuclear vertical gaze palsy), postural instability and falls, as well as Parkinsonian features and speech disturbances 1-3.

Jun 27, 2005 · Objective: To evaluate the area of the midbrain and pons on mid-sagittal MRI in patients with progressive supranuclear palsy (PSP), Parkinson disease (PD), and multiple-system atrophy of the Parkinson type (MSA-P), compare these appearances and values ...

Brain MRI was repeated in 2022 and revealed moderate midbrain atrophy, which is considered to be a supportive feature for PSP diagnosis. The characteristic “hummingbird” sign was observed on sagittal T1 images (see Figure 1 B).

In this case, combination of clinical presentation with atypical parkinsonism, eye movement abnormalities and characteristic MRI features make the diagnosis of progressive supranuclear palsy (PSP) highly likely. Case courtesy of Dr Raju Yerra.

Progressive supranuclear palsy (PSP) has many clinical features overlapping with other Parkinson syndromes and differentiation on clinical ground is difficult. This case highlights how a brain MRI can help diagnose PSP in settings with limited resources where histological diagnosis is …

Sep 28, 2014 · Investigation of choice is MRI. Mid brain atrophy is must. Hummingbird sign also known as the penguin sign on mid sagittal sections as in our case. The key is a flattening or concave outline to the superior aspect of the midbrain which should be upwardly convex.

Jul 6, 2022 · MRI measurements of the volume of the cerebrum is a very sensitive way to track the progression of PSP and is used in drug trials routinely to compare the rate of brain loss in the treatment group to that in the placebo group. But it doesn’t …

We reviewed MRI and brain specimens of six patients with PSP, nine with Parkinson's disease (PD) and six with striatonigral degeneration (SND). Sagittal T1-weighted images showed that four patients with PSP had obvious reduction of anteroposterior midbrain diameter.

May 14, 2013 · We aimed to develop in histolog-ically proven disease a simple measure of the midbrain and pons on sagittal MRI to identify PSP. Methods: Measurements of the midbrain and pontine base on midsagittal T1-weighted MRI were performed in confirmed PSP (n 12), Parkinson disease (n 2), and multiple system atrophy

Sep 1, 2024 · Progressive supranuclear palsy (PSP), also known as the Steele-Richardson-Olszewski syndrome, comprises a group of related tauopathies and is considered a neurodegenerative disease with no efficacious treatment. Epidemiology Progressive supran...