Perforin-1 Perforin (PRF), encoded by the PRF1 gene, is a pore-forming toxic protein housed in the secretory granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells.

Dec 25, 2024 · PRF1 (Perforin 1) is a Protein Coding gene. Diseases associated with PRF1 include Hemophagocytic Lymphohistiocytosis, Familial, 2 and Lymphoma, Non-Hodgkin, Familial. Among its related pathways are Signaling by ALK fusions and activated point mutants and Granzyme Pathway.

This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells.

The PRF1 gene provides instructions for making a protein called perforin. This protein is found in immune cells (lymphocytes) called T cells and natural killer (NK) cells, which destroy other cells.

Jan 4, 2025 · Gene target information for PRF1 - perforin 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Feb 8, 2025 · An intronic silencer of the mouse perforin gene. Perforin-mediated CTL cytolysis is critical for protective immunity to Listeria monocytogenes (Lm) capable of cell-cell spread, while protective immunity against spread-defective Lm is largely …

As a pore-forming toxin, perforin (PRF, encoded by the PRF1 gene) is stored in cytotoxic lymphocyte secretory granules. During the immune response, these “killer” cells form immune synapses with virally infected or cancerous target cells and …

Perforin (PRF, encoded by the PRF1 gene) is a pore-forming toxin (1, 2) stored in the secretory granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells (collectively known as cytotoxic lymphocytes, CLs) (3).

Perforin, a pore-forming toxin released from secretory granules of NK cells and CTLs, is essential for their cytotoxic activity against infected or cancerous target cells. Bi-allelic loss-of-function mutations in the perforin gene are invariably ...

Despite the major biological importance of perforin as a mediator of antiviral and anticancer immunity, the cis regulatory elements on mouse or human chromosome 10 that control perforin gene (PRF1) expression have long eluded our understanding.