Oct 22, 2008 · We provide evidence for the rapid upregulation of perforin protein, which may contribute to the ability of CD8 T cells to kill multiple targets over time. The δG9 clone …

We provide evidence for the rapid upregulation of perforin protein, which may contribute to the ability of CD8 T cells to kill multiple targets over time. The deltaG9 clone recognizes the …

Correlation between perforin and CD107A expressions in CD4+ (E) and CD8+ (F) lymphocytes. Perforin expression in T cells is not linked to COVID-19 severity. As perforin expression in T …

We provide evidence for the rapid upregulation of perforin protein, which may contribute to the ability of CD8 T cells to kill multiple targets over time. The dG9 clone recognizes the granule …

Moreover, perforin deficiency in CD8 + T cells mitigated both inflammation and depressive-like behaviors in mice with colitis. Mechanistically, perforin and granzyme B were found to …

We show that at the height of the immune response, the majority of conjugate-forming CD8 + CTL express high levels of perforin messenger RNA and protein, and kill essentially via perforin.

Natural killer (NK) cells and CD8-positive T-cells are the main source of perforin. However, CD4-positive T-cells are also able to express a low amount of perforin, when classic cytotoxicity is …

Mar 17, 2023 · CD8 T and NK cells mediate killing by delivery of perforin and granzyme B (GZB) stored in lysosome-like granules. We present a flow-cytometry-based protocol combined with …

Nov 16, 2004 · Based on this background, we addressed the question of whether perforin expression is differentially regulated in CD4 + and CD8 + CTLs. Methods: Herpes simplex …

Intracellular flow cytometry analysis of perforin production by CD8+ T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls.