Apr 15, 2008 · Flow cytometric immunophenotyping is a useful tool for the identification of abnormal plasma cells and for the distinction between lymphoid and plasma cell neoplasms. In addition, flow cytometric testing may provide additional prognostic information. 96 , 97 Table 5 outlines the normal pattern of staining and clinical utility of reagents ...

Plasma cells (PCs) are essentially characterized by the co-expression of CD138 and CD38, which allows their identification in flow cytometry in bone marrow (BM), peripheral blood, or cell suspensions from tissues.

Plasma cells are large lymphocytes with abundant cytoplasm and a characteristic appearance on light microscopy. They have basophilic cytoplasm and an eccentric nucleus with heterochromatin in a characteristic cartwheel or clock face arrangement.

Explore our interactive tool to find Plasma Cell Markers including CD19, Ly6K, CD27, and more. Discover reagents and assays for your research. View more!

May 16, 2022 · Plasma cells, also known as antibody-secreting cells or plasma B cells, arise when various B cell subsets encounter an antigen, present it on the cell surface via MHC II, and become activated by cognate interactions with T helper cells.

Sep 28, 2020 · In this study, we established flow cytometry-based protocols for the analysis of human plasma cell differentiation of primary B cells, which are suitable for the analysis of CVID patient samples .

Oct 20, 2017 · Multiparameter flow cytometry (MFC) has become standard in the management of patients with plasma cell (PC) dyscrasias, and could be considered mandatory in specific areas of routine clinical...

Flow cytometry immunophenotyping (FCM) is an integral part of the diagnosis, classification, and management of plasma cell neoplasms (PCNs).

Plasma cell myeloma (PCM) is a bone marrow (BM)-based, multifocal plasma cell (PC) neoplasm associated with the presence of M protein in serum and/or urine. Most cases involve disseminated tumor cells in BM.

Nov 5, 2021 · Growing evidence supports the quantification of circulating plasma cells (cPCs) measured by multiparameter flow cytometry (MFC) as a powerful diagnostic biomarker suitable for risk stratification of newly diagnosed transplant eligible MM (Garces et al, EHA 2021).