Podophyllotoxin (PPT) is the active ingredient in Podofilox, a medical cream used to treat genital warts and molluscum contagiosum. [2] . It is not recommended for HPV infections without external warts. [2] . It can be applied either by a healthcare provider or the patient themselves. [2]

Podophyllotoxin is an aryltetralin-type lignan isolated from species of Podophyllum [1, 2]. Two most common sources are the rhizomes of Podophyllum peltatum (American mayapple) and Sinopodophyllum hexandrum Royle (Barberry family) [1, 3]. These perennial herbs are distributed widely across the Himalayan region and Western China [4, 5, 6, 7].

Podophyllotoxin is an antimitotic. It acts by preventing viral wart cells from dividing and multiplying. Eventually all the wart cells die and new healthy cells grow in their place. For centuries, Native American tribes used the plant and its root for its medicinal, as well as poisonous, properties. Various uses of the plant included:

Jan 7, 2025 · Podophyllotoxin (PPT), also known as podofilox, is a medical cream that is used to treat genital warts and molluscum contagiosum. It is not recommended in HPV infections without external warts. It can be applied either by a healthcare provider or the person themselves.

For vaginal warts, allow to dry before removing the speculum. Do not use to treat genital warts in children. Do not apply to cervical, urethral, anorectal or oral warts. Do not apply to healthy skin. May cause local reactions: erythema, ulceration, pain in area where applied. Use a new applicator tip for each application. Avoid contact with eyes.

Jun 13, 2005 · Podofilox is a topical agent used for the treatment of external genital warts and perianal warts. A lignan found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic.

PTOX is an important plant-derived natural product, has derivatives such as etoposide and teniposide, which have been used as therapies for cancers and venereal wart. PTOX structure is closely related to the aryltetralin lactone lignans that have antineoplastic and antiviral activities.

Nov 8, 2023 · Podophyllotoxin is a topical preparation which is applied directly to the surface of the wart. It works by preventing the wart cells from dividing, which stops them from increasing in number. As the wart cells die, new healthy tissue grows in their place.

Apr 19, 2021 · It has recently been redeveloped for the purpose of treating cytokine storm in COVID-19 patients. Podophyllotoxin and its naturally occurring congeners have low bioavailability and almost all these initially discovered compounds cause systemic toxicity and development of drug resistance.

Podophyllotoxin is a plant-derived compound used primarily in topical treatments for certain skin conditions. It has antitumor properties and is commonly used in the treatment of warts, especially external genital warts and plantar warts.