Reactive oxygen species (ROS) are important signaling molecules, e.g., being required for autophagic degradation. SIRT1, a class III protein deacetylase, is a crucial cellular survival protein, which is also involved in combatting oxidative stress.

The AMPK-SIRT1-FOXO pathway affects enzymes responsible for ROS production through direct and indirect mechanisms. Among them, NADPH oxidase is one of the main sources of ROS production. The AMPK-SIRT1-FOXO pathway can reduce ROS generation by decreasing NOX expression or inhibiting its activity .

Nov 19, 2010 · SIRT1, an NAD +-dependent histone deacetylase, plays a critical role in endogenous reactive oxygen species (ROS)-triggered apoptosis in mouse ES (mES) cells by blocking nuclear translocation of p53 (Han eta al., Cell Stem Cell, 2008). Here, we investigated a possible role for phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/Akt ...

May 14, 2020 · Studies suggest that SIRT1 is involved in regulating ROS in vitro and in vivo. Modulating the levels of SIRT1 might be a strategy to combat ROS production and could be a novel target for therapy in various pathological conditions.

May 4, 2017 · Previous studies have shown that reactive oxygen species (ROS) is a key factor that contributes to the impairment of ECs and the subsequent endothelial dysfunction. The longevity regulator Sirt1 is a NAD + -dependent deacetylase that has a potential antioxidative stress activity in vascular ECs.

Sep 11, 2013 · SIRT1 (sirtuin-1), an NAD+-dependent protein deacetylase, decreases ROS levels and participates in cell survival under oxidative stress conditions. SIRT1 modulates the transcription factors p53, a tumor suppressor and inducer of apoptosis, and the forkhead O (FOXO) family, both of which play roles for cell survival and cell death.

Jan 1, 2021 · SIRT1 activates the defensive-signal cascade that plays as the frontline defense against ROS in human reproductive organs. SIRT1 deficiency cause cigarette smoking induced cell injury, insulin secretion and glucose homeostasis through PGC-1a.

These phenomena indicate that Sirt1 is upstream of ROS, and ROS bursts result in increased TRAF6 levels. Further, the activation of Sirt1 during the period of ischemia reduced ischemia-induced injury after 72 h of reperfusion in mice with middle cerebral artery occlusion.

Feb 11, 2013 · Reactive oxygen species (ROS) are important signaling molecules, e.g., being required for autophagic degradation. SIRT1, a class III protein deacetylase, is a crucial cellular survival protein, which is also involved in combatting oxidative stress.

Jun 15, 2024 · Our study confirms that miRNA-34a-5p could participate in oxidative stress responses caused by ROS and further regulate the inflammatory process via the SIRT1/p53 signaling axis, ultimately affecting the onset of OA, thus providing a new treatment strategy for clinical treatment of OA.