Reactive oxygen species (ROS) are important signaling molecules, e.g., being required for autophagic degradation. SIRT1, a class III protein deacetylase, is a crucial cellular survival protein, which is also involved in combatting oxidative stress.

SIRT1 and SIRT6 signaling networks in the heart protection. The diverse roles of SIRT1 and SIRT6 in the heart include protective effects against cardiac hypertrophy, I/R injury, oxidative stress injury, hearth failure, and autophagy. SIRT1 acts by deacetylating NF-κB, FOXO, and Akt.

May 4, 2017 · Previous studies have shown that reactive oxygen species (ROS) is a key factor that contributes to the impairment of ECs and the subsequent endothelial dysfunction. The longevity regulator Sirt1 is a NAD + -dependent deacetylase that has a potential antioxidative stress activity in vascular ECs.

In mammalian cells, seven sirtuins (SIRT1–7) modulate distinct metabolic and stress-response pathways, SIRT1 and SIRT3 having been most extensively investigated in the cardiovascular system. SIRT1 and SIRT3 are mainly located in the nuclei and mitochondria, respectively.

May 25, 2007 · Moderate overexpression of Sirt1 protected the heart from oxidative stress induced by paraquat, with increased expression of antioxidants, such as catalase, through forkhead box O (FoxO)-dependent mechanisms, whereas high levels of Sirt1 increased oxidative stress in the heart at baseline.

Jan 1, 2024 · Increasing research on I/R injury has indicated that SIRT1 is involved in the process of autophagy and regulates myocardial I/R. SIRT1 regulates autophagy through various pathways, such as the deacetylation of FOXOs, ATGs, and LC3.

Nov 1, 2015 · Signaling pathways of silent mating-type information regulation (Sirt) 1 in the heart. Sirt1 can modulate fatty acid oxidation, cardiac hypertrophy, apoptosis, oxidative stress, and autophagy through deacetylation of NF-κB, Akt, Forkhead box class O (FoxO), and p53.

Sep 13, 2020 · Then, we highlight the cardiomyocyte protection of the age-related proteins Sirtuin1 (SIRT1) and Sirtuin1 (SIRT3) in response to I/R injury, and we discuss their modulation of cardiac metabolism and the inflammatory reaction that is involved in ROS formation.

Aug 23, 2013 · Reactive oxygen species (ROS) is generated by oxidative stress and plays an important role in various cardiac pathologies. The SIRT1 signaling pathway and mitochondrial biogenesis play essential roles in mediating the production of ROS.

Jul 24, 2023 · We investigated whether resveratrol exerts cardioprotective effects by inhibiting ferroptosis via the Sirt1/p53 pathway. A heart failure model was established by aortic coarctation in Sirt1 knockout mice.