Betacoronavirus pandemicum [2] (colloquially known as Severe acute respiratory syndrome–related coronavirus, abbreviated as SARSr-CoV or SARS-CoV) [note 1] is a species of virus consisting of many known strains.

Dec 2, 2024 · To identify variants, scientists map the genetic material of viruses (known as sequencing) and then look for differences between them to see if they have changed. Since 2020, SARS-CoV-2, the virus that causes COVID-19, has been spreading and changing globally. These changes have led to the detection of variants in many countries around the world.

Mar 23, 2023 · Importantly, we argue that though SARS CoV-2, due to its proofreading exoribonuclease participating in genome error correction, has less mutation error rates than influenza A and B viruses, 7 it has evolved and is still evolving much faster in terms of transmissibility and immune evasion, and the causes might include the first ever global mass ...

Aug 19, 2024 · KP.3.1.1, of the Omicron family, is now the predominant SARS-CoV-2 variant circulating in the United States, having overtaken its parent linage KP.3 and previous KP.2 variants. KP.3.1.1 is the only major variant increasing in proportion nationally.

Nov 1, 2024 · KP.3.1.1, a descendant of KP.3, is the top variant in the United States, representing 54–60% of viruses nationally, and increases have slowed. XEC, a hybrid of two JN.1 variants, represents 14–22% of viruses and is increasing.

Mar 27, 2024 · It remains critical that global systems to detect signals of potential variants of interest (VOIs) or variants of concern (VOCs) and rapidly assess the risk posed by SARS-CoV-2 variants to public health are maintained, and data are shared, according to good principles and in a timely fashion.

Jul 1, 2024 · Leading the National SARS-CoV-2 Strain Surveillance (NS3) system. The NS3 program collects, analyzes, and shares information about the genetic diversity of SARS-CoV-2, the virus that causes COVID-19.

We herein report the RNA structure of SARS-CoV-2 3′ UTR by using a chemical probing strategy, namely dimethyl sulfate (DMS)-mutational profiling with sequencing (MaPseq) in virions and minigene-transfected cells.

Nov 30, 2024 · It is crucial to decipher the molecular basis of this L456-E493 mutational cooperativity to help understand the future evolution potential of KP.3-like variants and optimize the update of...

Mar 5, 2025 · Centers for Disease Control reports LP.8.1, XEC and KP.3.1.1 together constitute the majority of current national SARS-CoV-2 variants; current dominant variants are all susceptible to PEMGARDA.

SARS-CoV-2, SARS-CoV and MERS-CoV are zoonotic viruses that are highly pathogenic. Diseases caused by these viruses including COVID-19, SARS and MERS significantly impact infected individuals as well as the economies of infected countries.

Dec 10, 2018 · Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at...

May 18, 2022 · We evaluated neutralizing-antibody titers against the ancestral SARS-CoV-2 strain bearing the D614G mutation, along with the understudied BA.3 and deltacron variants, and compared the...

Nov 22, 2024 · In summary, we found that KP.3.1.1 and especially XEC showed enhanced humoral immune evasion and receptor-binding domain-targeting antibody escape capabilities, supporting the foreseeable dominance of the XEC variant of SARS-CoV-2.

Jul 9, 2021 · Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one...

Oct 24, 2024 · CDC’s national SARS-CoV-2 genomic surveillance program previously detected the emergence and circulation of major variants, including Delta and Omicron. What is added by this report? During May 2023–September 2024, SARS-CoV-2 lineages primarily comprised descendants of Omicron XBB and JN.1.

Jan 11, 2024 · As of November, 2023, SARS-CoV-2 XBB variants, including EG.5.1 (XBB.1.9.2.5.1), the currently predominant lineage, have been circulating worldwide, according to Nextstrain datasets.

Jun 27, 2024 · Overall, the JN.1 subvariants, including KP.2 and KP.3, showed increased immune evasion and R e compared with the parental JN.1. Moreover, LB.1 and KP.2.3 with Ser31del, showed higher pseudovirus infectivity and more robust immune resistance than KP.2.

Jun 27, 2021 · We show that SARS-CoV-2 nsp3.1 directly binds to ATF6 and can suppress the ATF6 stress response. Characterizing the host interactions of nsp3 widens our understanding of how coronaviruses co-opt cellular pathways and presents new avenues for host-targeted antiviral therapeutics. Keywords: Abbreviations: Pro.

Sep 10, 2024 · The SARS-CoV-2 Interagency Group evaluates SARS-CoV-2 variants and lineages circulating in the U.S. and makes recommendations about the classification of variants and lineages.

Feb 10, 2025 · As shown in the appendix (p 18), it is plausible to assume that the observed advantage of LP.8.1 over XEC in some countries might depend on the immune background or the history of SARS-CoV-2 infection, and vaccination of the population in each country. However, both live-virus and real-world data from more countries are needed to better ...

Apr 5, 2023 · This Review explores the mechanisms that generate genetic variation in SARS-CoV-2, underlying the within-host and population-level processes that underpin these events.

Upon exposure to sublethal or lethal SARS-CoV-2 virus infection, Pex5 ΔCd11c mice exhibited increased morbidity and reduced survival (Fig. 3, A and B). The increased vulnerability of Pex5 Δ Cd11c mice to infection was independent of viral load and time of clearance ( Fig. 3C ), suggesting that lung macrophage peroxisome deficiency does not ...

Esistono centinaia di altri ceppi correlati al SARS-CoV-1, tutti noti solo per infettare specie non umane: i pipistrelli sono il principale serbatoio di molti ceppi di coronavirus correlati alla SARS e sono stati identificati numerosi ceppi nelle civette delle palme, che sono state probabilmente gli antenati del SARS-CoV-1. [3] [4]Verso la fine del 2019 una nuova malattia si è manifestata con ...

2 days ago · The rush to study SARS-CoV-2 delivered effective vaccines, therapeutics, such as monoclonal antibodies, and actionable insights into the virus’s spread. “People’s mindsets changed,” says ...

Aug 16, 2024 · The SARS-CoV-2 virus responsible for COVID-19 uses its spike-shaped protein to attach to a particular enzyme on human cells, which begins a process that allows it to enter the cell. The spike protein has two main parts or "domains," the S1 domain and the S2 domain. Unlike the S1 domain, the S2 domain is similar across different coronaviruses ...