Feb 7, 2020 · Here, we summarised new insights into the role of SGOC metabolism in the progression of neuroblastoma (NB) with highly activated SGOC metabolism.

May 5, 2023 · This review comprehensively analyzes the expression pattern and metabolic flux of the SGOC pathway in multiple cancer backgrounds at the system level and to describe the possible role of the SGOC metabolic network in tumor immunotherapy and ferroptosis.

Jun 17, 2024 · Serine–glycine-one-carbon (SGOC) metabolism was screened out to be responsible for the aggressive malignant properties and poor prognosis in HNSCC patients. A 4-SGOC gene prognostic...

Aug 1, 2019 · Here we report that neuroblastoma cells with MYCN amplification show increased transcriptional activation of the serine-glycine-one-carbon (SGOC) biosynthetic pathway and an increased dependence on this pathway for supplying glucose-derived carbon for serine and glycine synthesis.

Oct 1, 2020 · This review will focus on the participation of serine and glycine in the mitochondrial one-carbon (SGOC) pathway during cancer progression, with an emphasis on the genetic and epigenetic determinants that drive SGOC gene expression.

Nov 25, 2015 · The serine, glycine and one-carbon (SGOC) network is a complex, cyclic system that converts serine and glycine into metabolic outputs necessary for cells to accomplish a myriad of biological functions.

Nov 20, 2014 · Flux analysis of serine shows that gene expression patterns can predict flux. The serine, glycine, one-carbon (SGOC) metabolic network is implicated in cancer pathogenesis, but its general functions are unknown.

A novel, robust 4-gene signature based on SGOC was developed to stratify HNSCC patients into high- and low-risk groups. The differences in the TME and response to therapies were analyzed. Furthermore, the anti-tumor efficacy of novel metabolic-targeted drugs was evaluated in …

Jun 17, 2024 · Serine-glycine-one-carbon (SGOC) metabolism was screened out to be responsible for the aggressive malignant properties and poor prognosis in HNSCC patients. A 4-SGOC gene prognostic signature, constructed by LASSO-COX regression analysis, demonstrated good predictive performance for overall survival and therapeutic responses.

This review comprehensively analyzes the expression pattern and metabolic flux of the SGOC pathway in multiple cancer backgrounds at the system level and to describe the possible role of the SGOC metabolic network in tumor immunotherapy and ferroptosis.