Suggested roles that Sirt1-mediated deacetylation plays in the development of the pathological hallmarks of Alzheimer’s disease, including the development of Aβ plaques and neurofibrillary tangles, through the modulation of AβPP cleavage pathways and tau degradation.

In recent years, the role of sirtuins in Alzheimer's disease (AD) has become increasingly apparent. Growing evidence demonstrates that sirtuin 1 (SIRT1) regulates many processes that go amiss in AD, such as: APP processing, neuroinflammation, …

In this study, SIRT1 was shown to deacetylate the acetylated tau and consequently reduces its level; conversely, SIRT1 inhibition leads to the opposite effect—increasing the levels of tau and exacerbating the accumulation of pathogenic forms of phosphorylated tau.

In this study, SIRT1 expression was found to promote alpha-secretase activity and attenuates Abeta peptides in primary Tg2576 neuron cultures and CHO-APPswe cells. In another study, SIRT1 was also shown to protect against microglia-dependent amyloid-beta toxicity in cells through inhibiting inflammatory NF-kappaB signaling (Chen et al., 2005).

Aug 4, 2023 · Sirtuin-1 (Sirt1), encoded by the SIRT1 gene, is a conserved Nicotinamide adenine dinucleotide (NAD+) dependent deacetylase enzyme, considered as the master regulator of metabolism in humans. Sirt1 contributes to a wide range of biological pathways via several mechanisms influenced by lifesty …

Aug 1, 2010 · We will present recent evidence indicating that Sirt1 may protect against Alzheimer's disease by interfering with the generation of β-amyloid peptides. We will discuss Sirt1 as a potential novel target, in addition to the development of Sirt1 activators for the prevention and treatment of Alzheimer's disease.

Dec 1, 2016 · SIRT1 deacetylation of histones and transcription factors impinge on multiple neuronal and non-neuronal targets, and modulates stress response, energy metabolism and cellular senescence/death pathways.

Apr 16, 2013 · Sirtuin (SIRT) pathway has a crucial role in Alzheimer’s disease (AD). The present study evaluated the alterations in serum sirtuin1 (SIRT1) concentration in healthy individuals (young and old) and patients with AD and mild cognitive impairment (MCI).

Feb 25, 2025 · SIRT1 is an enzyme involved in cellular stress resistance, DNA repair, and regulation of inflammation (Davenport et al. 2014). By activating SIRT1, these drugs can help reduce oxidative stress, inflammation, and neuronal damage, which are key contributors to AD progression (Wong and Tang 2016).

Jan 11, 2021 · There is compelling evidence to support the fact that SIRT1 and SIRT2 are shuttled between the nucleus and cytoplasm and perform context-dependent functions in neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD).