Jul 25, 2008 · Here, we show that SIRT1, an NAD(+)-dependent protein deacetylase, is required for high-magnitude circadian transcription of several core clock genes, including Bmal1, …

SIRT1 regulates the acetylation status of clock components and controls circadian amplitude of clock genes. However, the mechanisms responsible for this circadian clock control have been …

Given that cellular NAD + levels are coupled to metabolic activity, the identification of SIRT1 as a histone deacetylase that counteracts CLOCK function brings this protein with its extensive …

Jun 20, 2013 · SIRT1 is a NAD + -dependent protein deacetylase that governs many physiological pathways, including circadian rhythm in peripheral tissues. Here, we show that SIRT1 in the …

Oct 28, 2022 · SIRT1 as circadian clock machinery regulator. SIRT1 is a protein, expressed in a circadian manner, that regulates the acetylation status of clock components and controls …

SIRT1, a nicotinamide adenine dinucleotide (NAD +)-dependent sirtuin, has been shown to promote cell survival by inhibiting apoptosis or cellular senescence in mammalian cells.

Jun 20, 2013 · SIRT1 is a NAD (+)-dependent protein deacetylase that governs many physiological pathways, including circadian rhythm in peripheral tissues. Here, we show that …

Mar 12, 2009 · SIRT1 is recruited to the Nampt promoter and contributes to the circadian synthesis of its own coenzyme. Using the specific inhibitor FK866, we demonstrated that …

New information regarding sirtuin-dependent control of the circadian clock has emerged. In addition to SIRT1 and SIRT3, SIRT6 has been demonstrated as a critical regulator of circadian …

In the liver, SIRT1 acts by ensuring proper circadian oscillation in hepatocytes through rhythmic deacetylation of histone H3 at the promoter of clock-controlled genes (CCGs), as well as …