Results: Resveratrol dose-dependently inhibited TNF-α-induced cyclooxygenase-2 (COX-2), MMP-1, MMP-3, MMP-13 and PGE(2) production in human chondrocytes. Moreover, MMP-2 …

This study aimed to determine the potential role of SIRT1 in AQP2 expression induced by tumor necrosis factor-alpha (TNF-α) and to disclose the underlying mechanism in renal inner …

Overexpression of Sirt1 in the cells significantly attenuated TNF-α-induced injury through suppressing apoptosis, increasing ALP activity, and increasing the expression of Runx2 and …

Knockdown of Sirt1 by RNA interference caused 3T3 cells susceptible to TNF-α stimulation and diminished anti-inflammatory effect of resveratrol. We also explored potential anti-inflammatory …

Nov 17, 2016 · Collectively, our findings, for the first time, elucidate a precise mechanism for attenuation of HgCl 2 -induced liver dysfunction by dietary luteolin via regulating …

Nov 21, 2019 · This study is the first to identify that SIRT1 is a miR-155 target, which promotes TNF-α-induced senescence via the SIRT1/FoxO-1/p53/p21 pathway in HUVECs, and is also …

Mar 1, 2013 · Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blotting were performed to detect gene products and proteins involved in tumor …

Mar 6, 2024 · Silent information regulator 1 (SIRT1) is a NAD + -dependent class III deacetylase that plays important roles in the pathogenesis of numerous diseases, positioning it as a prime …

Feb 3, 2025 · An increase in PC12 cell apoptosis occurs when TNF-α is administered simultaneously with a MAPK inhibitor, as well as when the MAPK inhibitor is given before the …

SIRT1 activation by resveratrol reduces the activation of T cells, the production of TNF-α and IL-12, and the expression of CD28 and CD80 and upregulates CTLA4 expression in collagen …