
Sirtuin 2 - Wikipedia
SIRT2 sensitizes cells to the action of insulin by physically interacting with and activating Akt and downstream targets. SIRT2 mediates mitochondrial biogenesis by deacetylating PGC-1α, …
SIRT2 Gene - GeneCards | SIR2 Protein | SIR2 Antibody
Dec 25, 2024 · SIRT2 (Sirtuin 2) is a Protein Coding gene. Diseases associated with SIRT2 include Thrombocytopenia and Retinoblastoma. Among its related pathways are Cell Cycle, …
SIRT2: Controversy and multiple roles in disease and physiology
Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the …
Multiple Roles of SIRT2 in Regulating Physiological and …
Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. …
The sirtuin family in health and disease | Signal Transduction and ...
Dec 29, 2022 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are …
Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of ...
May 23, 2021 · As a type of nicotinamide adenine dinucleotide (NAD +)-dependent deacetylases, sirtuin 2 (SIRT2) is predominantly found in the cytoplasm of cells in the central nervous system …
Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase activity
Sirtuin 2 (Sirt2) is a member of the sirtuin family of NAD-dependent lysine deacylases and plays important roles in regulation of the cell cycle and gene expression. As a nucleocytoplasmic …
Human Sirtuin 2 Localization, Transient Interactions, and ... - PubMed
Human sirtuin 2 (SIRT2) is an NAD +-dependent deacetylase that primarily functions in the cytoplasm, where it can regulate α-tubulin acetylation levels. SIRT2 is linked to cancer …
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases
SIRT2 inhibits colony formation in glioma cell lines (Hiratsuka et al., 2003) and arrests chromosomal instability by getting down-regulated. SIRT2 is associated with …
The Human Sir2 Ortholog, SIRT2, Is an NAD - Cell Press
May 7, 2002 · Here, we report that a human ortholog of Sir2p, sirtuin type 2 (SIRT2), is a predominantly cytoplasmic protein that colocalizes with microtubules. SIRT2 deacetylates …