Oct 13, 2011 · The sclerotic skin manifestations of cGVHD (ScGVHD) result from inflammation and fibrosis of the dermis, subcutaneous tissue, or fascia, leading to significant functional disability. Risk factors and clinical markers associated with ScGVHD remain largely unexamined.

Graft-versus-host disease (GVHD) is an immune-mediated reaction and a major complication following allogeneic hematopoietic stem cell transplantation (HSCT). It can affect between 40 and 60% of patients, depending on host and donor factors, and accounts for …

Sclerodermatous graft-versus-host disease (GVHD) is a rare complication of bone marrow transplantation. While GVHD is often associated with the beneficial graft vs. tumour effect, it also contributes towards significant morbidity and mortality.

Lichenoid and sclerodermoid changes are the two main cutaneous presentations of chronic GVHD. Sclerodermoid GVHD was first described by Master et al. in 1975 and is considered a severe form of the disease eventually making the patient disabled.

Chronic Graft-versus-Host Disease (Gvhd) Chronic GVHD can manifest as scleroderma or lichenoid variant [ 17 ]. In the first case, the sclerosis appears to depend on excessive tissue repair, caused by immunologic injury induced by lymphocytic hyperactivity.

CHRONIC GRAFT-VS-HOST disease (cGVHD) usually appears at least 2 to 3 months after allogenic bone marrow transplantation (BMT).

Jun 10, 2021 · Acute graft versus host disease (GVHD) consists of tender, erythematous macules that may coalesce over time. Patients with chronic GVHD exhibit skin changes that resemble either lichen...

Mar 15, 2002 · Murine sclerodermatous graft-vs-host disease (Scl GVHD) models human scleroderma, with prominent skin thickening, lung fibrosis, and up-regulation of cutaneous collagen mRNA. Fibrosis in Scl GVHD may be driven by infiltrating TGF-beta1-producing mononuclear cells.

Jun 5, 2010 · We assessed age, sex, pre-transplant diagnosis, conditioning regimen, GVHD prophylaxis, and occurrence of acute GVHD (aGVHD), chronic lichenoid and chronic systemic GVHD, and clinical properties of sclerodermatous GVHD.

Use Chronic GVHD Diagnosis and Staging Tool to document clinical signs regularly. Sclerodermoid disease is the most serious form of cutaneous GVHD because if left untreated is irreversible. The superficial form is morphoea-like and deep sclerotic disease is scleroderma-like.