Sec61, termed SecYEG in prokaryotes, is a membrane protein complex found in all domains of life. As the core component of the translocon, it transports proteins to the endoplasmic …

Nov 1, 2017 · Recently, cryoelectron tomography of translocons in native ER membrane vesicles, derived from human cell lines or patient fibroblasts, and even intact cells has given …

These structural data are discussed in light of different Sec61 channel activities including ribosome receptor function, membrane insertion, and translocation of newly synthesized …

May 11, 2023 · Here we present near-atomic-resolution structures of human Sec61 inhibited by a comprehensive panel of structurally distinct small molecules—cotransin, decatransin, …

Oct 5, 2022 · The Sec61 complex appears to be a good candidate to explain the mechanism of Ca 2+-store depletion associated with ER stress and UPR. The role of the Sec61 complex in …

Apr 28, 2017 · In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave …

Sec61 is a eukaryotic homolog of the translocation channel SecYEG, which plays a crucial role in protein secretion and localization within cells. You might find these chapters and articles …

Apr 28, 2017 · In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave …

The Sec61 channel consists of three subunits (Sec61α, Sec61β, Sec61γ in mammals; Sec61, Sbh1, Sss1 in yeast), two of which (Sec61 and Sss1) are essential in yeast (Mandon et al., …

In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave first insights …