Dec 13, 2024 · The autoantibody is called aquaporin-4-immunoglobulin G, also known as AQP4-IgG. Testing for this autoantibody can help healthcare professionals distinguish between NMO and MS and make an early diagnosis of NMO.

Antibodies to aquaporin-4 (called NMO-IgG or AQP4-Ab) constitute a sensitive and highly specific serum marker of neuromyelitis optica (NMO) that can facilitate the differential diagnosis of NMO and classic multiple sclerosis.

Recently, antibodies to the most abundant water channel in the central nervous system, aquaporin-4 (AQP4), have been found in patients with NMO. 1 These antibodies, referred to as AQP4-Ab or NMO-Ab, have been detected in 60% to 90% of patients with NMO and have been shown to correlate with NMO disease activity. 1,3 NMO-Ab have also been ...

AQP4 FACS analysis was done for serum samples from 36 random patients with a diagnosis of NMO. All samples were tested with our validated AQP4 CBA assay. Thirty samples (83.33%) were positive by FACS and 29 samples (80.55%) were positive by CBA.

Laboratory testing involves determining AQP4 IgG and MOG IgG serum antibody status; the presence of AQP4 or MOG IgG is confirmatory for NMOSDs in the appropriate clinical setting.

Aquaporin-4 Antibody (IgG), CBA - Antibody to Aquaporin 4 causes neuromyelitis optica (NMO), a demyelinating disease of the central nervous system often confused diagnostically with multiple sclerosis (MS) and/or transverse myelitis.

Oct 20, 2021 · Aquaporin 4-immunoglobulin G selectively targets at aquaporin 4, the predominant water channel protein abundantly expressed in astrocytes, initiates complement-dependent cytotoxicity against astrocytes, leading to axonal, and myelin impairment (10, 11).

Aquaporin-4 (AQP4) (NMO-IgG) Antibody with Reflex to Titer, Serum - NMO (neuromyelitis optica, Devic disease) is an immune- mediated chronic inflammatory disease that predominantly affects the optic nerve and spinal cord and presents with optic neuritis (ON) and myelitis.

Aug 21, 2023 · Useful in the initial evaluation of neuromyelitis optica (NMO) spectrum disorders. This test uses a cell-based assay (CBA) to detect antibodies against aquaporin-4. ||Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.15 mL) Serum separator tube (SST) or …

Neuromyelitis optica (NMO) immunoglobulin G (IgG) (aquaporin-4 [AQP4] IgG) is highly specific for NMO and related disorders, and autoantibody detection has become an essential investigation in patients with demyelinating disease.