Nov 1, 2023 · Robust IFN-γ secretes in the activated STING pathway, which can inhibit the system X c − and activate the GPX4 pathway, leading to LPO accumulation for ferroptosis therapy. Therefore, our MRI contrast agent FeGd-HN@TA-Fe 2+-SN38 can be used for immunoferroptosis synergistic therapy of tumors.

To overcome the problems of Gd‐based contrast agents (GBCAs) and stimulator of interferon genes (STING) agonists, in this study, a Turbo‐charging system‐like GBCA termed as Turbo S are designed and constructed for MRI‐guided STING pathway‐activated cancer immunotherapy.

To solve these problems, in this study, we developed a STING pathway-activatable contrast agent (i.e., FeGd-HN@TA-Fe 2+-SN38 nanoparticles) for magnetic resonance imaging (MRI)-guided tumor immunoferroptosis synergistic therapy.

Nov 3, 2024 · To overcome the problems of Gd‐based contrast agents (GBCAs) (nephrotoxicity and brain deposition) and stimulator of interferon genes (STING) agonists (poor stability, low delivery efficiency,...

Apr 3, 2024 · Herein, we report α-phase manganese sulfide nanotheranostics (MnSN) as an MRI-guided chemodynamic therapy agent and cGAS-STING agonist for tumor immunotherapy. MnSN can degrade into manganese ions in response to the mildly acidic tumor microenvironment.

To overcome the problems of Gd‐based contrast agents (GBCAs) (nephrotoxicity and brain deposition) and stimulator of interferon genes (STING) agonists (poor stability, low delivery efficiency, and potential toxicity), in this study, a Turbo‐charging system‐like GBCA is designed and constructed for magnetic resonance imaging (MRI) guided ...

Aug 1, 2023 · Based on the synergistic mechanisms of ferroptosis, immunosuppression reversal and disulfidptosis, the intelligent nanomedicine GOx-IA@HMON@IO can be used for MRI-guided tumor therapy with excellent biocompatibility and safety.

Mechanistically, DOX could kill cancer cells while Mn 2+ could significantly increase the activity of STING pathway related protein to amplify the STING signal and has the function of MRI T 1 imaging. The nanoplatform could promote the presentation of tumor antigens and activate a robust innate and adaptive immunity, providing reference for the ...

May 30, 2023 · Here, we developed a manganese-phenolic network platform (TMPD) to boost antitumor immunity via a stimulator of interferon gene (STING)-amplified activation cascade. TMPD is based on doxorubicin (DOX)-loaded PEG-PLGA nanoparticles and further coated with manganese (Mn 2+ )-tannic acid (TA) networks.

Nov 3, 2024 · So, to overcome the aforementioned challenges associated with GBCAs and STING agonists, a Turbo-charging system-like GBCA, termed as Turbo S, was designed and constructed for MRI-guided STING pathway-activated cancer immunotherapy.