Granzymes (Gzms), a family of cytotoxic proteases, are key players in cytotoxic T lymphocyte (CTL) elimination of target cells. Gzms are also expressed by other immune cells, such as …

Granzymes are a family of serine proteases, composed of five human members: GA, B, H, M and K. They were first discovered in the 1980s within cytotoxic granules released during NK cell- …

Nov 1, 2004 · Here we characterize the single-cell expression pattern of granzymes A and B in human lymphocytes using a flow cytometry-based assay. We demonstrate that most …

Jan 15, 2010 · In this study, we discuss the role of granzymes as central factors in antitumor immunity, as well possible roles for these proteases as instigators of inflammation. Cytotoxic T …

Granzymes are serine proteases released by cytoplasmic granules within cytotoxic T cells and natural killer (NK) cells. They induce programmed cell death (apoptosis) in the target cell, thus …

May 22, 2015 · It describes the cellular and biochemical mechanisms that are responsible for protecting cytotoxic T lymphocytes and natural killer cells from endogenous cytotoxic perforin …

Dec 1, 2021 · In SSc, IgG4-RD, and primary Sjorgen syndrome patients, granzyme-producing CD4 T cells were elevated in both the blood (∼20–60% of total blood CD4 T cells in IgG4-RD …

Jun 15, 2022 · Using T cell receptor repertoire data, we found that CD8 GzmK + GzmB + T cells are clonally expanded in synovial tissues and maintain their granzyme expression and overall …

Feb 6, 2022 · Granzymes are a family of cytotoxic proteases that each act on unique sets of biological substrates within target cells, usually to induce cell death. Granzymes are …

It is important to know whether naive as well as memory T cells acquire granzyme B when cytokine-stimulated and also if the cells can respond without dividing.