In this study, we employed two fluorophore-labeled and thiol-modified DNAs. The long-term stability of the thiol–gold bond as a function of time, salt, temperature, pH, and organic solvent …

Feb 18, 2022 · Here, we discover that both thiolated and non-thiolated DNA/RNA can be efficiently attached to AuNPs to achieve high-stable spherical nucleic acid (SNA) within …

Sep 25, 2019 · Here we present bioorthogonal approaches for making DNA-protein conjugates required in force spectroscopy experiments.

Researchers have anchored various DNA probes on the surface of AuNPs, and studies have shown that the surface of AuNPs can form strong covalent bonds with thiol groups, readily. …

Thiol modifiers (-SH) allow the covalent attachment of oligonucleotides to a variety of ligands or supports during or after solid phase synthesis of DNA or RNA oligonucleotides. A thiol-modifier …

Apr 16, 2012 · The attachment of thiolated DNA to gold nanoparticles (AuNPs) has enabled many landmark works in nanobiotechnology. This conjugate chemistry is typically performed using a …

When you say "thiol labelling", do you mean a protocol for incorporating the thiol groups into the DNA/RNA, or one for adding a modification (e.g. biotin) to a thiol group?

May 6, 2010 · We describe a general protocol for the site-specific and covalent coupling of any type of biomolecule that can be prepared with a free thiol group. The protocol uses a poly …

May 1, 2002 · Using microcantilever-based sensors with integrated readout, we demonstrate in situ quantitative studies of surface-stress formation during self-assembly of a 25-mer thiol …

The internal Thiol Modifier can be placed within a molecule, which will then fragment the flanking regions at the disulfide bond. This can be used for intentional breakage of the oligo into two …