Thiolysis is a reaction with a thiol (R-SH) that cleaves one compound into two. [1] Thiolysis involves the addition of coenzyme A to one of the products. This reaction is similar to hydrolysis, which involves water instead of a thiol. [2] This reaction is seen in β-oxidation of fatty acids. [3]

Thiolysis of epoxides constitutes practically the most useful protocols for the synthesis of β-hydroxy sulfides, which serve as important intermediates for the synthesis of a rich family of molecules of biological interest and natural products. A number of convenient procedures to realize this reaction are based on the use of bases or Lewis acids.

The process, called thiolysis (as distinct from hydrolysis), yields the two-carbon fragment acetyl coenzyme A and a fatty acyl coenzyme A having two fewer carbon atoms than the molecule that underwent reaction [22]; otherwise the two are similar.

Jul 28, 2022 · Fatty acid oxidation takes place in four stages - dehydrogenation, hydration, oxidation, and thiolysis. These four stages keep repeating until the whole molecule is oxidized. Each of these four stages is catalyzed by a different enzyme.

Feb 16, 2024 · To describe the reactions needed to completely oxidize a fatty acid to carbon dioxide and water. Like glucose, the fatty acids released in the digestion of triglycerides and other lipids are broken down in a series of sequential reactions …

Jan 31, 2025 · The process, called thiolysis (as distinct from hydrolysis), yields the two-carbon fragment acetyl coenzyme A and a fatty acyl coenzyme A having two fewer carbon atoms than the molecule that underwent reaction [22]; otherwise the two are similar.

Thiolases, also known as acetyl-coenzyme A acetyltransferases (ACAT), are enzymes which convert two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway.

Meaning of thiolysis medical term. What does thiolysis mean?

Oct 17, 2023 · The alpha oxidation pathway involves a series of enzymatic reactions that ultimately lead to the breakdown of fatty acids. The main steps of this pathway include activation, hydration, oxidation, and thiolysis.

Thiolysis is a chemical reaction in which a bond between two carbon atoms is broken by another molecule containing a thiol group, resulting in the formation of a new molecule and the release of a CoA molecule.