The translocon (also known as a translocator or translocation channel) is a complex of proteins associated with the translocation of polypeptides across membranes. [1] In eukaryotes the …

Sep 15, 2000 · An attractive candidate for the vehicle that mediates such transport is the translocon. This complex is comprised of several membrane proteins that form an aqueous …

Feb 21, 2003 · Translocon coupling facilitates protein import into mitochondria and chloroplasts. Protein import into mitochondria and chloroplasts occurs simultaneously across both the outer …

A translocon is a molecular complex that receives protein substrates for translocation across a membrane. It can target substrates either cotranslationally during protein synthesis or …

Recent studies have revealed that the translocon is a complex and sophisticated molecular machine that regulates the movement of polypeptides through the bilayer, apparently in both …

Jan 25, 2023 · The near-complete atomic model of the most abundant ER translocon variant comprising the protein-conducting channel SEC61, TRAP and the oligosaccharyltransferase …

Oct 19, 2022 · We have defined the modular composition of the multipass translocon, established its role in multipass protein topogenesis, and revealed how nascent substrates drive …

Feb 4, 2020 · The endoplasmic reticulum (ER) translocon complex is the main gate into the secretory pathway, facilitating the translocation of nascent peptides into the ER lumen or their …

Jan 15, 2021 · Here, we introduce a fluorescence-based strategy to detect aberrant N-glycosylation in individual cells and identify a regulatory role for the heterotetrameric …

Apr 14, 2021 · In eukaryotes, oligosaccharyltransferase (OST) associates with the co-translational translocon to glycosylate nascent polypeptides and facilitates post-translocational …