The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3 ), by replacing each hydrogen atom by a fluorine atom.

A trifluoromethyl group is defined as a substituent in organic chemistry with unique stereoelectronic properties, characterized by high electronegativity and close Van-der-Waals radii. It plays a crucial role in drug-receptor interactions by increasing lipophilicity and improving transport characteristics of bioactive molecules.

Apr 29, 2024 · trifluoromethyl-benzene - cas 98-08-8, synthesis, structure, density, melting point, boiling point

Trifluoromethylation in organic chemistry describes any organic reaction that introduces a trifluoromethyl group in an organic compound. [1][2][3][4] Trifluoromethylated compounds are of some importance in pharmaceutical industry and agrochemicals.

Oct 11, 2022 · Among them, most of the compounds were found to have fluorine or fluorine-containing functional groups exhibiting numerous pharmacological activities. Herein, we summarized the trifluoromethyl (TFM, -CF3)-group-containing FDA …

Aug 10, 2015 · Here we report a strategy for the use of trifluoroacetic anhydride for a scalable and operationally simple trifluoromethylation reaction using pyridine N -oxide and photoredox catalysis to...

Nov 1, 2014 · Drawing inspiration from this prospect, we have designed the present review article providing a brief outline of the recent advances in the trifluoromethylation methodology in connection with some CF 3 -containing drug candidates currently under the development by the pharmaceutical industries.

Sep 16, 2016 · The trifluoromethyl group has become an important structural component of many bioactive compounds, mainly because of its polar influence and its effect on the lipophilicity of compounds. This chapter gives a few illustrative examples of important agrochemicals and pharmaceuticals that contain a CF 3 group are given as follows.

Mar 13, 2014 · Herein we present a general and reliable method for the synthesis of trifluoromethyl group-containing N -heteroaromatics through highly regioselective addition of a trifluoromethyl nucleophile...

Apr 23, 2021 · The trifluoromethyl group plays an increasingly important role in pharmaceuticals, agrochemicals and materials. This tutorial describes recent advances in trifluoromethylation of carbon-centered radical intermediates.