The C-terminal domain of YY1 has a nuclear localization signal leading to its primary localization in the nucleus. 1 YY1 can also undergo a DNA-replication-associated switch in its localization …

Here we analyzed expression, activity, and subcellular localization profiles of YY1 during Xenopus laevis development. Abundant levels of YY1 mRNA and protein were detected in early stage …

Nov 28, 2005 · YY1 nuclear localization and activity is significantly increased during the onset of the G1/S phase, followed by increased cytoplasmic localization in the late S phase with …

YY1 conditional knock-out indicated that YY1 is required for B cell development, at least in part, by controlling long-distance DNA interactions at the immunoglobulin heavy chain and Igκ loci. …

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of …

Feb 23, 2016 · Numerous mechanisms have been shown to regulate the function of YY1, such as its associated co-factors, subcellular localization, post-translational modifications including poly...

Through co-localization with ERα, YY1 assists the binding of ERα to the enhancer region, a specific active regulatory region associated with H3K27ac marks, on downstream genes and …

Jan 22, 2004 · These findings reveal a mechanism by which YY1 localization is coupled to DNA synthesis and responsive to cell-cycle signaling pathways. Taken together, our results provide …

Jan 26, 2004 · The DNA synthesis inhibitor aphidicolin caused a nearly complete loss of nuclear YY1, whereas addition of caffeine or 2-aminopurine to aphidicolin-treated cells restored both …

Aug 8, 1998 · Fluorescence in situ hybridization with the YY1 clone has localized the YY1 gene to chromosome 14 band q32. A major YY1 gene transcription initiation site has been mapped to …