Myelin oligodendrocyte glycoprotein (MOG) antibody associated disorders (MOGAD) are a spectrum of idiopathic, inflammatory, demyelinating diseases affecting the central nervous system (CNS).

Jan 21, 2025 · MOG antibody disease (MOGAD) is a neurological, immune-mediated disorder in which there is inflammation in the optic nerve, spinal cord and/or brain. Myelin oligodendrocyte glycoprotein (MOG) is a protein that is located on the surface of myelin sheaths in the central nervous system.

MOG (myelin oligodendrocyte glycoprotein) antibody disease (MOGAD) or MOG antibody-associated encephalomyelitis (MOG-EM)[1] is an inflammatory demyelinating disease of the central nervous system.

Feb 12, 2025 · Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) represents a group of inflammatory demyelinating disorders united by the presence of IgG antibodies to myelin oligodendrocyte glycoprotein (MOG).

Anti-MOG syndrome is an autoimmune disorder in which the immune system mistakenly attacks myelin oligodendrocyte glycoprotein (MOG). This protein is located on the surface of myelin, an insulating layer that protects nerve cells and helps facilitate communication between them.

MOG IgG antibody titers may assist in monitoring disease course and prognosis, but their role is imperfect. Antibody titers may increase but may not be predictive of relapses or attacks. MOG IgG antibodies may become undetectable with immunosuppression, but this does not necessarily indicate clinical response.

Mar 10, 2024 · Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune condition where your immune system attacks proteins in the protective cover around your nerves (myelin). It causes symptoms that affect your eyes, brain and spinal cord, like vision loss, confusion and muscle weakness. Treatment options are available.

Sep 9, 2021 · MOGAD is a condition that causes inflammation in the nervous system. In MOGAD, antibodies attack a protein called myelin oligodendrocyte glycoprotein (MOG). MOG is found on the protective...

Jan 3, 2024 · MOG antibody testing with a cell-based assay. This test looks at cells with MOG on their surface to see if the MOG -antibody is present in the blood. This test is considered the gold standard for testing for MOGAD, but there is potential for false positives.

There are no FDA-approved medications for maintenance in MOG antibody disease, so anything prescribed is done off-label. The primary therapies used in the US are mycophenolate mofetil (CellCept), rituximab (Rituxan), azathioprine (Imuran), and repeated IVIG infusions or subcutaneous immunoglobulin.