LogP is used in the pharmaceutical/biotech industries to understand the behavior of drug molecules in the body. Drug candidates are often screened according to logP, among other criteria, to help guide drug selection and analog optimization.

LogP is defined as the partition coefficient of a molecule between aqueous and lipophilic phases usually considered as octanol and water. It is determined experimentally by dissolving the …

LogP is an important component of Lipinski’s Rule of 5 recommendations which predicts the drug-likeness of a new synthetic compound. According to Lipinski’s Rule of 5, an oral drug should have a LogP value <5, ideally between 1.35-1.8 for good oral and intestinal absorption.

Sep 3, 2022 · LogP gives you an indication of how well the molecule will partition into the organic elution solvent. The higher the logP, the more likely the compound will partition from the SLE phase into the organic elution solvent like dichloromethane, ethyl acetate or MTBE.

LogP is the log of the partition coefficient of a solute between octanol and water, at near infinite dilution. LogP is widely used in drug discovery and development as an indicator of potential utility of a solute as a drug.

Dec 14, 2022 · One way to quickly assess the suitability of a drug is to experimentally determine its log P and log D values, which we will discuss in this article. The log P and log D of a compound are functional parameters for assessing the bioavailability of a drug. Log P is a ratio of the compound’s solubility in water vs. its solubility in 1-octanol.

LogP measures the logarithm of ration between the concentration of a compound in a non-polar solvent and in water. It is common practice to measure this using octanol (PubChem 2003) as the non-polar solvent. Mathematically LogP is defined like \[\text{LogP} = \log \frac{[\text{Drug}]_{\text{non-polar}}}{[\text{Drug}]_{\text{water}}}\]

Molecular physical properties play an important role in aiding our understanding of the behavior of compounds in the real world. The values of molecular physical properties such as logP, logD, solubility, and pKa can help us evaluate and predict the likely behavior of …

Oct 29, 2024 · LogP and logD are important values to consider during drug design as both give insight to the lipophilicity and hydrophilicity of compounds.

logP. The logP value, representing a compound's partition coefficient between octanol and water, is a critical parameter in computer-aided drug design (CADD) and various molecular applications due to its direct correlation with a compound`s lipophilicity.