mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration.

What are MTOR inhibitors? Mammalian target of rapamycin (mTOR) inhibitors block the activity of the mammalian target of rapamycin. Mammalian target of rapamycin is a protein kinase, which …

A growing cancer cell divides in two: mTOR inhibitors such as everolimus help regulate cellular processes in cancer. The target of rapamycin (known as mTOR or the mechanistic target of …

Sep 15, 2022 · In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges …

Aug 1, 2024 · mTOR inhibitors are used to treat certain types of cancer, organ transplant rejection, a genetic disorder called tuberous sclerosis complex (TSC), and more. These …

A mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies. An mTOR inhibitor immunosuppressant used to prevent organ transplant …

Mar 14, 2022 · What is mTOR inhibitor? mTOR is classified as a drug that inhibits the mechanistic target of rapamycin (mTOR). mTOR stands for serine/threonine-specific protein kinase found …

Jun 21, 2024 · mTOR inhibitors primarily target mTORC1, thereby reducing protein synthesis and promoting autophagy. The most well-known mTOR inhibitor is rapamycin, also known as …

Rapamycin inhibits mTOR by associating with its intracellular receptor FKBP12. The FKBP12-rapamycin complex binds directly to the FKBP12-Rapamycin Binding (FRB) domain of mTOR, …

There are three commercially available mammalian (mechanistic) target of rapamycin (mTOR) inhibitors the US Food and Drug Administration (FDA) approved in the United States: …