Mar 9, 2017 · The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors.

Mar 28, 2022 · The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator of metabolism, integrating diverse nutritional and hormonal cues to control anabolic processes, organismal physiology, and even aging.

Oct 2, 2023 · Here, we provide the detailed structure of mTOR, its complexes, and the comprehensive role of upstream regulators, as well as downstream effectors of mTOR signaling cascades in the...

Aug 23, 2023 · The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such as the levels of...

Nov 13, 2018 · The atypical serine/threonine kinase mTOR is a master regulator of cell growth and metabolism. mTOR promotes anabolic processes such as ribosome biogenesis and protein, nucleotide, fatty...

May 31, 2018 · We will focus on the recent findings about the role of mTOR complex (mTORC) pathways in the regulation of energy balance and metabolism in key metabolic tissues, including adipose tissue, liver, skeletal muscle, pancreas and the brain.

Mar 18, 2025 · A 2019 review in Nature Reviews Molecular Cell Biology discussed mTOR’s role in lipid metabolism, showing that its activation enhances sterol regulatory element-binding proteins (SREBPs), increasing lipid biosynthesis. Dysregulated mTOR signaling is implicated in cancer and metabolic disorders, where excessive activation contributes to ...

The mechanistic Target of Rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in ...

Jul 1, 2021 · The mechanistic target of rapamycin (mTOR), master regulator of cellular metabolism, exists in two distinct complexes: mTOR complex 1 and mTOR complex 2 (mTORC1 and 2).

Consistent with its role in coordinating anabolic and catabolic metabolism at the cellular level, physiological studies in mice have revealed that mTOR signaling is essential for proper metabolic regulation at the organismal level as well.