N-acyl amides are a general class of endogenous fatty acid compounds characterized by a fatty acyl group linked to a primary amine metabolite by an amide bond.

N -acyl amino acids (NAAAs) are an important family of endogenous signaling molecules in which an amide bond covalently links an amino acid to the acyl moiety of a long-chain fatty acid.

An aminoacyl-tRNA, with the tRNA above the arrow and a generic amino acid below the arrow. Most of the tRNA structure is shown as a simplified, colorful ball-and-stick model ; the terminal adenosine and the amino acid are shown as structural formulas .

The N-acyl conjugates of amino acids and neurotransmitters (NAANs) have recently come to prominence because of their potential roles in the nervous system, vasculature and the immune system. NAAN are compounds such as glycine, GABA or …

Sep 1, 2021 · N-acyl amino acids (NAAs) are amphiphilic molecules, with different potential fatty acid and head group moieties. NAAs are the largest family of anandamide congener lipids discovered to date.

Dec 3, 2019 · Here, we review the current knowledge of the mechanisms for the biosynthesis and inactivation of the N-acyl amino acids, as well as the various molecular targets for some of the N-acyl amino acids described so far.

Dec 5, 2023 · Amide bond-containing biomolecules are functionally significant and useful compounds with diverse applications. For example, N-acyl amino acids (NAAAs) are an important class of lipoamino acid amides with extensive use in …

The N -acyl amino acids are members of the fatty acid amide family with an amino acid as the biogenic amine. The occurrence of N -acylated amino acids in biological systems has long been known.

Sep 17, 2020 · Using quantitative proteomics, here we show that PM20D1 circulates in tight association with both low- and high-density lipoproteins. Lipoprotein particles are powerful co-activators of PM20D1 activity in vitro and N-acyl amino acid biosynthesis in vivo.

Topics that are covered in this minireview are: biosynthetic pathways for N- acyl amino acids, receptors for N- acyl amino acids, physiologic actions of N- acyl amino acids, pharmacological effects of N- acyl amino acids, and molecular mechanisms believed to …